Inhibition of miR-216b profoundly decreased the proliferation of HCC SMMC-7721 cells by regulating insulin-like growth factor 2 mRNA-binding protein 2, while overexpression of miR-216b inhibited replication of hepatitis B virus and proliferation of human hepatoblastoma HepG2.215 cells (24). This evidence concerns the gene IGF2BP2 and hepatocellular carcinoma.