The binding energy of initiator Caspase 9 with lactococcin mmfii (−9.2 Kcal/mol) and plantaricin JLA-9 (−8.8 Kcal/mol) along with executioner Caspase 3 with lactococcin A (−8.3 Kcal/mol) and bacteriocin 28b (−8.1 Kcal/mol) further justifies the potential role of probiotics in inducing apoptosis in CRC cells. Here, CASP9 is linked to colorectal carcinoma.