Strikingly, bacteriocins, namely, plantaricin JLA-9, plantaricin W, lactococcin A, and lactococcin mmfii, show the highest binding affinity with the crucial CRC promoting protein COX-2, initiator caspase CASP9 of the apoptosis pathway, stress-induced metabolic pathway mediator PI3K, and immunomodulatory IL18R. This evidence concerns the gene PIK3CA and colorectal carcinoma.