We found a marked enrichment of SNPs annotated in the OMIM database to be linked with non-brain cancers and craniofacial disorders, as well as three SNPs in biosynthetic genes (ACO1, HS6ST1, and GALNT10) and two SNPs in homeobox genes (SIX1 and ONECUT1) among the nine SNPs shared by all four NLDs. The gene discussed is SIX1; the disease is brain cancer.