A previous study has reported that hypomethylation of a specific promoter CpG site of sortilin 1 in endothelial colony-forming cells from MMD was related to endothelial cell function, implying the involvement of hypomethylation of sortilin 1 in MMD pathogenesis (Sung et al., 2018) Recently, a study reported that men with lung cancer showed extensive autosomal DNA hypomethylation and a significantly increased risk of death (Willis-Owen et al., 2021). The gene discussed is SORT1; the disease is lung cancer.