The association between an elevated preoperative CA125 level and poor prognosis was further confirmed by multivariate analysis (HR, 2.36; 95% CI, 1.67–3.33, P < 0.001) after adjusting with anemia (HR, 1.35; 95% CI, 1.04–1.75, P = 0.026), elevated preoperative CEA (HR, 1.50; 95% CI, 1.14–1.97, P = 0.004), clinical T stage (HR, 1.43; 95% CI, 1.09–1.88, P = 0.01), multiple metastasis (HR, 1.62; 95% CI, 1.25–2.11, P < 0.001), post-operative complication (HR, 1.91; 95% CI, 1.19–3.07, P = 0.008), and post-operative chemotherapy (HR, 0.50; 95% CI, 0.38–0.65, P < 0.001) (Table 3). Here, CEACAM5 is linked to anemia.