In addition to ASD behavioral traits, intellectual disability with delayed language and motor skills, cognitive impairment, and ADHD behaviors, patients also display a variety of developmental abnormalities including craniofacial dysmorphism, syndactyly, joint hypermotility, and growth retardation, suggesting critical roles of KDM6B in embryonic and postnatal development. The gene discussed is KDM6B; the disease is attention deficit-hyperactivity disorder.