The results showed that compared to wild-type controls, male heterozygous Kdm6b-KO mice had a significantly increased number of entries into the open arms (t = 5.08, df = 14, p = 0.0002) and spent more time in running along the open arms (t = 4.93, df = 14, p = 0.0002), while wild-type and mutant female mice had a similar number of entries into the open arms (t = 0.457, df = 12, p = 0.6558) and running time (t = 0.5767, df = 12, p = 0.5748), suggesting that the Kdm6b haploinsufficiency reduced anxiety-like behaviors in male mice under a highly stressful condition (Figures 4I–M). The gene discussed is KDM6B; the disease is Anxiety.