Accordingly, to detect the proteins on the hTERT promoter in breast cancer cells, we performed a ChIP assay and found that the RFPL-3 proteins bound to the hTERT promoter region in breast cancer cells, especially MDA-MB-231 cells, were higher than that in normal breast cells (Figure 5(a), Figure S6A). The gene discussed is RFPL3; the disease is breast carcinoma.