In animal experiments, by adding aPL monoclonal antibody isolated from the serum of APS patients to DVT mice, the risk and degree of thrombosis were increased, the content of CitH3 in the thrombus was higher than that of the control group, and the level of serum DNA was also increased, validating the mechanism by which aPL promotes thrombosis by stimulating NETs release (Meng et al., 2017). The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.