Using the rhADAMTS13 protease to specifically cleave vWF, thrombolysis was observed in animal thrombosis models, and the combination of rhADAMTS13 and DNase I effectively improved myocardial infarction by reducing the interaction of vWF with neutrophils and NETs in myocardial tissue of mice (Kelly et al., 2018). The gene discussed is VWF; the disease is deep vein thrombosis.