LGALS3 and neoplasm: The intracellular release of LCP inhibits the activity of galectin-3, which increases the affinity of major histocompatibility complex (MHC) proteins on tumor cell membrane for NKG2D on NK cell membranand, and then increases the tumor cell apoptosis, inhibits the invade ability, and enhances the recognition ability of NK cells to tumor cells in melanoma cells after PDT.