Similarly, Yang et al., used Network pharmacology approach combined with molecular docking to investigate the Potential Mechanism of Jintiange Capsule for the treatment of Osteoporosis and found that calcium phosphate (the main active ingredient), may interact with CALR and CALM1 targets and regulate multiple signaling pathways to treat osteoporosis (Yang et al., 2021). This evidence concerns the gene CALR and osteoporosis.