A meta-analysis by Nassan et al. showed that muskelin (MKLN1) was related with early-onset BD (in patients ≤ 19 years) and that MKLN1 mediated cellular trafficking of the gamma-aminobutyric acid-A (GABA-A) receptor, which indicated that GABA-A may be associated with early-onset BD. This evidence concerns the gene MKLN1 and Behcet disease.