In recent years, two independent studies identified de novo variants in MAPK8IP3 in individuals presenting with intellectual disability as well as brain anomalies including perisylvian polymicrogyria, cerebral or cerebellar atrophy, and hypoplasia of the corpus callosum (Iwasawa et al., 2019; Platzer et al., 2019). The gene discussed is MAPK8IP3; the disease is Intellectual disability.