- Abnormal insulin signaling pathway in obesity can relate to COVID-19 resistance and mortality- Adipose tissue has reservoir-like effects for COVID-19, where lipid droplets in tissues facilitate virus spread- Obesity patients possess longer COVID-19 symptoms due to viral shedding- Adipose tissue secreted IL-6, a marker of COVID-19 severity- Overabundance of amino acids can trigger mTOR pathway, supporting SARS-CoV-2 replication through utilization of host viral replication and subsequent inflammation. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.