CRP and obesity due to melanocortin 4 receptor deficiency: Hence, as a result of obesity, inflammation may increase due to the unregulated secretion of cytokines and adipokines such as IL-6, tumor necrosis factor, and C-reactive protein (CRP), resulting in the creation of a self-regenerating inflammation loop; causing the utilization of immune cells such as T cells, B cells, and macrophages; and impairing the immune system (72, 74).