- Over-activated immune response could induce deterioration of cardiac function in fulminant myocarditis- Increased circulating cytokines promote inflammatory infiltration in off-target organs, especially the heart- Use of immune-related therapeutic drugs could trigger both injury directly induced by cardiac inflammation and indirect cardiac injury caused by systemic inflammation- Patients with hypertension have an increased risk for severe infection- Hypertension might cause CD8+ T cell dysfunction. This evidence concerns the gene CD8A and myocarditis.