DSG3 and pemphigus: However, beside the reports of altered contents of desmosomal components along different epidermal layers (7) and changes in the distribution of cytoskeleton-bound and not cytoskeleton-bound fractions caused by pemphigus autoantibodies (11–13), little is known about detailed changes in the composition of desmosomes regarding the pemphigus autoantigens Dsg1 and Dsg3 during maturation of keratinocytes across the epidermal layers.