Our study found that the key genes COG8 and GIMAP6 were related to the upregulation of ISG15 and IFIH in DM skin lesions, suggesting that COG8 and GIMAP6 may be involved in the occurrence and development of DM and may mediate the infiltration of CD4+ T cells in DM through regulatory genes. The gene discussed is COG8; the disease is dermatomyositis.