found that in glioma cells, HNRNPA2B1 could contribute to the packaging of circNEIL3 into exosomes and delivery to infiltrating tumor-associated macrophages in TME, allowing them to acquire immunosuppressive characteristics by stabilizing IGF2BP3, which in turn facilitates the progression of glioma (164). The gene discussed is IGF2BP3; the disease is central nervous system cancer.