METTL3 relies on IGF2BP1 to extend the half-life of chromo box 8 (CBX8) mRNA, which recruits Pol II and KMT2B to the promoter of leucine-rich repeat sequence of G protein-coupled receptor 5 (LGR5) and maintains the H3K4me3 state, ultimately maintaining CRC stemness and promoting its drug resistance (86). This evidence concerns the gene METTL3 and colorectal carcinoma.