METTL14 could modulate its target mRNAs, such as MYB and MYC, by m6A modification, which was negatively modulated by SPI1, demonstrating the role of SPI1-METTL14-MYB/MYC signaling axis in hematopoiesis and AML cells (131). The gene discussed is MYB; the disease is acute myeloid leukemia.