YTHDF2 and acute myeloid leukemia: Studies have shown that overexpression of YTHDF2 in AML cells causes decreased half-life of a wide range of m6A transcripts, including TNF receptor superfamily member 2 (TNFRSF2) transcripts, which could help maintain the function of leukemic stem cells, and enhanced hematopoietic stem cell activity when YTHDF2 is knocked down (134).