In vitro experiments, YTHDF1 and YTHDF2 knockdown in NSCLC cells upregulated tumor PD-L1 expression and changed a variety of immune-related genes, while high expression of YTHDF1 and YTHDF2 was associated with good prognosis, a large number of tumor-infiltrating lymphocytes, and downregulation of PD-L1 in NSCLC patients (168). This evidence concerns the gene CD274 and neoplasm.