demonstrated that knockdown of METTL14 in tumor-associated macrophages drives CD8+ T cell differentiation along a dysfunctional trajectory that impairs CD8+ T cells to eliminate tumors, and METTL14-deficient C1q+ tumor-associated macrophages display reduced m6A abundance of the cytokine subunit Ebi3 and elevated levels of transcripts (157). The gene discussed is CD8A; the disease is neoplasm.