METTL3 expression was observed to be significantly upregulated in cutaneous squamous cell carcinoma (cSCC) tissues, and knockdown of METTL3 led to a significant decrease in the level of the undifferentiated marker k14 and a significant increase in the early differentiation marker K10 in cSCC cells, significantly inhibiting the stem cell-like properties of cSCC cells (137). Here, METTL3 is linked to cutaneous squamous cell carcinoma.