FTO promoted leukemia oncogene mediated cell transformation and leukemia by reducing m6A levels in mRNA transcripts, inhibited all-trans retinoic acid (ATRA) induced AML cell differentiation, and modulated the expression of its target genes such as retinoic acid receptor alpha (RARA) and ankyrin repeat and SOCS box containing 2 (ASB2) (132). This evidence concerns the gene RARA and acute myeloid leukemia.