found that in glioma cells, HNRNPA2B1 could contribute to the packaging of circNEIL3 into exosomes and delivery to infiltrating tumor-associated macrophages in TME, allowing them to acquire immunosuppressive characteristics by stabilizing IGF2BP3, which in turn facilitates the progression of glioma (164). This evidence concerns the gene HNRNPA2B1 and central nervous system cancer.