The upregulated genes, such as natriuretic peptide receptor (NPR)2, ADCY1, ADCY4, ADCY6, ADCY9, and LOC102483497 related to adenylate cyclase and guanylate cyclase activities in the DEGs may explain the damage mechanism of the light-sensitive photoreceptor outer segment, where phototransduction occurs, and the metabolic-related inner segment during the development of uveitis in tree shrews. The gene discussed is ADCY4; the disease is uveitis.