The high-risk group enriched numerous pathways associated with immune-inflammatory activation and metabolic disorders, such as leukocyte activation involved in immune response, macrophage activation, neutrophil extracellular trap formation, positive regulation of interleukin-1 production, NOD-like receptor signaling pathway, TNF signaling pathway, reactive oxygen species metabolic process, and regulation of actin cytoskeleton (Figures 8A, B). The gene discussed is TNF; the disease is metabolic disease.