To evaluate degranulation of neutrophil populations from COVID-19 patients, we compared expression of plasma membrane markers of the 4 neutrophil granule subsets, CD35 (secretory vesicles), CD11b (gelatinase granules), CD66b (specific granules), and CD63 (azurophilic granules), among HD NDN, COVID NDN, and COVID LDN before and after stimulation (Figure 2A). The gene discussed is ITGAM; the disease is COVID-19.