• FGL2 and CCL2 induce Treg to inhibit antigen presentation• MIF decreased GADC migration and maturation• Inhibit GADC maturation by STAT3 signaling pathway• Inhibit costimulatory factors CD80 and CD86 by VEGF, expressed VEGF is expressed by tumor cells and influenced by mutant IDH1 and IDH2. This evidence concerns the gene IDH2 and neoplasm.