Toll-like receptor 2, one of the HMGB receptors, is believed as correlation with NETs production, and HMGB1-mediated TLR2 signaling plays a critical role in eliciting glioblastoma regression, However, further studies are still needed to clarify the protumor and antitumor functions of NETs in glioma. Here, HMGB1 is linked to central nervous system cancer.