Glioma-derived Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes activation of GAMs and production of CCL5 (Figure 1B), which further induce a series of calcium-dependent pathways such as p-PYK2 and p-CAMKII that lead to glioma progression (35). The gene discussed is CAMK2G; the disease is central nervous system cancer.