HIF1A and colon adenocarcinoma: The HRGPI-high group was presented as higher activity of the HIF-1 pathway, a higher score of angiogenesis process, and a higher infiltration level of immune cells and stromal cells than the HRGPI-low group, inclining to present more obvious hypoxia patterns than cluster B. The immune characteristics in the HRGPI-high group were similar to those in cluster B, while those in HRGPI-low were similar to those in cluster A, which indicated that our HRGPI could accurately evaluate and quantify the hypoxia-related characteristics of patients with COAD.