• High quality of life can be achieved with a single agent (41)• Mildly effective for joint symptoms (58)• MTX combination is effective for joint symptoms (33, 58)• Steroid and MTX combinations are effective for joint symptoms (59)• MTX combination is effective for uveitis (60)• Effective for joint symptoms and uveitis (20)• MTX combination is effective for joint symptoms and uveitis (43, 57)• Steroid and MTX combinations are effective for joint symptoms and uveitis (41)• CRP and other laboratory values improve with MTX (57). This evidence concerns the gene CRP and uveitis.