IL1B and cryopyrin-associated periodic syndrome: Nevertheless, we observe an overproduction of IL-1β in peripheral blood monocytes extracted from CAPS patients and the macrophages established from CAPS patients-derived induced pluripotent stem (iPS) cells compared to healthy controls (18, 19), whereas a reduced response to MDP to produce inflammatory cytokines in the peripheral blood of patients with Blau syndrome were reported (20, 21).