Likewise, in B16-SIY tumors, combination therapy resulted in an increase in the percentage of tumor-infiltrating CD4+ T cells and CD8+ IFN-γ+ double positive T cells, whereas a significant decrease in the percentage of tumor infiltrating Foxp3+ Tregs was observed in anti-4-1BB/anti-CD73 Abs-treated mice (96). This evidence concerns the gene FOXP3 and neoplasm.