On the other hand, MUC16 has been associated with long-term survival of pancreatic cancer patients, inducing the activation of T cells reactive to MUC16 neoantigens in response to primary tumors, which are progressively lost during metastasis development (169), attesting that mucin activities are very complex and are strictly related to specific cancer contexts showing different interactions among stromal, cancer, and immune cells. This evidence concerns the gene MUC16 and familial pancreatic carcinoma.