Although these experimental and clinical studies have revealed that elevated circulating ANGPTL4 exerts deleterious effects on TRLs (VLDL, IDL, and chylomicrons) metabolism, it is necessary to further explore the interaction between circulating ANGPTL4, metabolic syndrome, and multiple metabolic traits, such as SUA, cholesterol, and glucose. This evidence concerns the gene ANGPTL4 and metabolic syndrome.