Overall 30-day mortality was only associated with admission IL-6 levels (HR = 1.013/ng/l; 95% CI 1.007–1.019; p < 0.001) and NSE at day 3 after arrest (HR = 1.013/μg/l; 95% CI 1.004–1.022; p = 0.005) in multivariate analysis (Table 2A), whereas impaired neurological outcome including deceased patients was associated with IL-6 (HR = 1.004/ng/l; 95% CI 1.001–1.007; p = 0.036), NSE (HR = 1.018/μg/l; 95% CI 1.004–1.032; p = 0.011), a history of diabetes, non-public arrest and a primary non-shockable rhythm (Table 2B and Supplementary Figure 3). Here, ENO2 is linked to diabetes mellitus.