RNLS and chronic kidney disease: Moreover, the most recent data (20) shows that genetic deletion of renalase results in significantly more severe cisplatin-induced chronic kidney disease, and that renalase agonist peptide (RP81) supplementation, via mesoscale nanoparticles, decreases inflammatory cytokines plasma levels, and preserves epithelial components of the nephron, and the vasculature, and suppresses inflammatory macrophages and myofibroblasts.