Renalase deficiency, in vivo, results in left ventricular hypertrophy, elevated blood pressure, electrolyte disturbances, and a significant degree of myocardial necrosis, whereas renalase application in vitro provides cardio protection by functioning as plasma NADH oxidase, effectively regulating extracellular NAD+ levels. The gene discussed is RNLS; the disease is hyperinsulinemic hypoglycemia, familial, 4.