We determined: (1) if and how ADF affects weight loss, glucose metabolism, and insulin sensitivity in type 2 diabetic mice; (2) if and how ADF affects circulating adipokines and their expression in adipose tissue; (3) how ADF rescues endothelial dysfunction, and if and how adipokines, including adiponectin, resistin, and leptin, modulated by ADF may contribute to the vascular benefits of ADF; and (4) whether and to what extent ADF influences glucose metabolism and vascular function in non-diabetic control mice. Here, RETN is linked to endothelial dysfunction.