The possible mechanisms of hawthorn leaf extracts on diabetic nephropathy attributed to increasing SOD and nitric oxide (NO, and decreasing the blood urea nitrogen (BUN), creatinine (Cr), triglyceride (TG), MDA levels, urine protein concentration, 38mitogen activated protein kinase (38MPAK) protein expression, and improving the histopathological changes of kidneys tissue. Here, SOD1 is linked to diabetic kidney disease.