It has been shown, in T2DM, that hepatic insulin receptors 1A (IR-1A) deficiency is associated with an increase in gluconeogenesis, suppressing of glycogen synthesis, elevating the levels of hemoglobin A1c (HbA1C), and upregulating of glucose transporter 2 (GLUT2) and G6Pase mRNAs and downregulating of glycerol kinase (GK) mRNA. The gene discussed is GK; the disease is type 2 diabetes mellitus.