Some studies have reported that CMKLR1-, GPR1-and chemerin-knockout mice show glucose intolerance (Takahashi et al., 2011; Ernst et al., 2012; Rourke et al., 2014; Wargent et al., 2015) whereas other studies show little to no effect on glucose homeostasis in mouse-mutant models (Rouger et al., 2013; Gruben et al., 2014). The gene discussed is CMKLR2; the disease is Glucose intolerance.