Visceral and subcutaneous expression of chemerin increases with obesity (Chakaroun et al., 2012) and local effects of chemerin on adipose tissue have been demonstrated in the proliferation of adipose tissue through hyperplasia (Jiang et al., 2018) and angiogenesis (Kaur et al., 2010) although conflicting results have been found in mouse mutant models (Helfer and Wu 2018). The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.