The aim of this study was to use the combination of ICA and a method of multivariate cross-classification (MVCC) (19) to discriminate between patients with anti-LGI1 encephalitis whose metabolic disorders within the medial temporal lobe and the basal ganglia were not able to be visually detected from their PET images (referred to as non-CD patients) and healthy participants. This evidence concerns the gene LGI1 and encephalitis.