CD4 and metastatic malignant neoplasm in the lymph nodes: Even in the same type of cancer, Gu‐Trantien et al found that CD4+ T cell immune infiltrates, principally located in TLS germinal centers, suggest a good prognosis by promoting anti‐tumor immunity in breast cancer [19], while TLSs in breast cancer were associated with higher tumor grade, low representation of intratumoral immune cells, and a high frequency of lymph node metastasis, as reported by Figenschau et al [20].