As inverted-repeated sequences are present in the intronic regions flanking VEGFA exon 7 (Fig. 7a and Supplementary Fig. 4a, b), we cloned this DNA fragment in a pCDNA3.1 expression vector, which showed high expression efficiency of circ_0076611 when transfected in BC cells (Fig. 7b). The gene discussed is VEGFA; the disease is breast cancer.