In addition, serum insulin levels and homeostasis model assessment-estimated insulin resistance (HOMA-IR) were significantly lower in the DSK group than in the HFD group (Serum insulin levels were 2.8 ± 2.9 ng/mL, 7.0 ± 1.1 ng/mL, and 1.0 ± 0.6 ng/mL in the SD, HFD, and DSK groups, respectively, p < 0.05; HOMA-IR were 34.9 ± 27.6, 96.0 ± 14.8, and 13.0 ± 7.4 in the SD, HFD, and DSK groups, respectively, p < 0.01; Fig. 2B). The gene discussed is INS; the disease is Insulin resistance.