The expression levels of other hub genes CTLA4, CXCL10, CCL5, CCl4, ICAM1, CXCL9, CD27, GZMB, FCGR2A, SELL, IDO1 in SKCM were higher than those in non-tumor skin tissues (P < 0.05, Fig. 4), and the results were statistically significant. The gene discussed is IDO1; the disease is neoplasm.