TLR7 and infection: While we have shown that combining bNAb therapy with TLR7 stimulation during ART delays or prevents viral rebound in macaques starting ART 1 week post-infection3, Hsu et al. have found that macaques treated with ART at 2 weeks post-infection followed by bNAbs PGT121 and N6-LS and TLR7 agonist administration had a more modest effect11, potentially due to the strong anti-drug antibody responses to N6-LS.