JAG1 and posterior cortical atrophy: Furthermore, our luciferase gene reporter assay showed that mutations in the interacting region of miR-628 effectively upregulated the JAG1-Luc activity, confirming the binding of miR-628 to the UTR of JAG1. Next, we observed that miR-628 overexpression in PCa cell lines effectively decreased levels of multiple JAG1 downstream targets.