Some studies have shown that HOXA10 functions in the regulation of proliferation, migration, and invasion and has been reported as a less aggressive tumor phenotype10 whereas HOXC10, which regulates oral tumorigenesis through Wnt-EMT signaling pathways, might play a pivotal role in metastasis of OSCC (oral squamous cell carcinoma) as studied in an in vivo xenograft model11. This evidence concerns the gene HOXC10 and oral cavity squamous cell carcinoma.