Further, the subnetwork driven regulatory analysis showed HOX genes interactions with the cell cycle regulators (GMNN, CDKN2A, CDC associated proteins), other families of homeobox genes (TBX4, FOXO1, FOXC1, MEIS, PBX, POU2F1) and the proto-oncogenes (JUN, HRAS, BRAF) leading to the alterations of various cancer related signaling pathways. This evidence concerns the gene JUN and cancer.