Basal and compensatory glycolysis rates (i.e., glycolysis rate measured following mitochondrial inhibition) were higher in vehicle versus UNC0642, UNC0638, and BIX01294 treated cells (Fig. 5A, Supplementary Fig. 5D), SESN2 (Fig. 5B) and EHMT2 knockdown cells (Fig. 5C, Supplementary Fig. 5E) suggesting that G9a inhibition decreases the glycolytic flux in T-ALL. Here, SESN2 is linked to acute lymphoblastic leukemia.