G9a modulation significantly (P < 0.05; Log2 fold-change ≤ −0.5 or ≥ 0.5) altered expression of 3% of transcribed genes (1448); with nearly 55.5% downregulated and 44.5% upregulated, supporting the notion that, depending on tumor types [21, 22], G9a mediated H3K9 methylation can both promote and suppress gene transcription. Here, EHMT2 is linked to neoplasm.