Consistent with this, vehicle controls had higher oxygen consumption rate (OCR) compared to UNC0642 treated (Fig. 5F), SESN2 (Fig. 5G) and EHMT2 (Supplementary Fig. 5G and 5I) knockdown T-ALL cells indicating that G9a inhibition may also negatively affect the rate of mitochondrial respiration and therefore the capability of the cells to compensate for the inhibition of glycolysis with an increase of the oxidative phosphorylation. This evidence concerns the gene SESN2 and acute lymphoblastic leukemia.