Notably, co-overexpression of circMETTL3 with sh-RUNX3 inhibited the promotion effects on CRC cell proliferation, migration, and invasion mediated by shRUNX3 (Fig. 4B–E), demonstrating that RUNX3 inhibits CRC proliferation and migration via circMETTLE3. Here, RUNX3 is linked to colorectal carcinoma.