For example, the hypomethylation of the BrCa DM CpG cg15699386 (on 1q22 in the intronic region of MUC1) increases the risk of BrCa and (as seen in the i-MeWAS and conventional differential methylation analysis results) is consistent with the effect of its most significant predictor meQTL SNP (rs4971059) on BrCa risk. The gene discussed is MUC1; the disease is invasive breast carcinoma.