To determine whether Smurf2 protein expression is upregulated in human lung tumors treated with chemoRT, we analyzed tumor samples from patients with stage III NSCLC before any treatment (pre-chemoRT group, n = 7) and after cisplatin chemotherapy and lung radiation followed by surgery (post-chemoRT group, n = 8). The gene discussed is SMURF2; the disease is non-small cell lung carcinoma.