CST3 and cystinosis: The authors of a 3-month study of 23 cystinosis patients less than 18 years old without renal replacement therapy, concluded that the addition of oral NAC 25 mg/kg/day to cysteamine standard of care caused a reduction in oxidative stress, based on a decrease in serum thiobarbituric acid-reactive substances (TBARS) (p < 0.0001), an improvement in renal function (based on levels of serum cystatin C), creatinine levels, and creatinine clearance [14].