In this study, we defined the cutoff values of CSF Aβ42, P-tau181, and T-tau for AD diagnosis (A+: Aβ42 < 933 pg/mL; T+: P-tau181 > 48.7 pg/mL; N+: T-tau > 313 pg/mL) in a Chinese cohort. Here, MAPT is linked to Alzheimer disease.