The populations of CD3+ tumor-infiltrating T lymphocytes (TILs), Teffs (CD8+), and activated Teffs (CD8+CD69+) in primary and distant tumors of HPNP-injected mice were higher than that of proteins-, HNP-, or PNP-injected mice after sono-irradiation (Fig. 5a–c, Supplementary Figs. 26–30). The gene discussed is CD8A; the disease is neoplasm.