Out of the genes that have a role in the BRCA1/2 HR pathway (Additional file 3), NCCN Guidelines (version 2.2021) indicate that the risk of triple negative breast cancer is potentially increased in patients with P/LP variants in BRIP1, RAD51C and RAD51D [9, 49, 50]. This evidence concerns the gene BRCA1 and triple-negative breast carcinoma.