WT1 and Denys-Drash syndrome: In addition to causing ISRNS, WT1 gene mutations can also result in Denys-Drash syndrome (DDS), Frasier syndrome (FS), WAGRS, which are often accompanied by male pseudohermaphroditism, hypospadias and other urological malformations, gonadal tumors, Wilms’ tumor, and other manifestations [1, 3, 16].