Children with ISRNS caused by WT1 gene mutations progress to ESRD 0.1 to 11 years after the onset, which is not only about 10 years faster than those without gene mutations, but also than faster those with hereditary nephrotic syndrome caused by mutations in other genes (e.g., NPHS2, NPHS1, PTPRO, and LAMB1) [17]. The gene discussed is PTPRO; the disease is nephrotic syndrome.