It has also been reported that cyclosporine (CsA) effectively reduced urine protein in hereditary nephrotic syndrome caused by WT1 gene mutations, and therefore, calcineurin inhibitors (FK506 and CsA) have a certain effect in the treatment of hereditary nephrotic syndrome caused by WT1 gene mutations, which may be achieved by stabilizing the podocyte actin cytoskeleton [1, 12, 14, 15]. Here, WT1 is linked to familial nephrotic syndrome.