A large number of putative suppressor genes that are silenced or activated by aberrant methylation have been identified in ovarian cancer, including hypermethylation of OPCML, RASSF1, CDKN2B as well as classical tumor suppressors BRCA1, p16 and MLH1, and hypomethylation of LINE-1, SLC6A12 and PRAME [30–38]. The gene discussed is OPCML; the disease is ovarian cancer.