Recent studies making use of hepatocyte-directed small interfering RNA (siRNA) for AGT in rats displaying hypertension and renal injury [spontaneously hypertensive rats (SHRs), deoxycorticosterone acetate-salt-treated hypertensive rats, and five-sixths nephrectomy rats], or liver-targeted AGT antisense oligonucleotides in normotensive cynomolgus monkeys yielded the same conclusions (Uijl et al., 2019, 2021; Bovée et al., 2021; Kukida et al., 2021). Here, AGT is linked to hypertensive disorder.