Given that ACE2 is the main cell entry receptor for SARS-CoV-2, there may be a role for soluble ACE2 proteins to act as a decoy in COVID-19 (Batlle et al., 2020b; Wysocki et al., 2021; Hassler et al., 2022), preventing viral internalization. The gene discussed is ACE2; the disease is COVID-19.