AGT and Nephropathy: In other diabetic animal models, including Zucker rats (a genetic obesity animal model caused by mutation in the leptin receptor), Otsuka Long-Evans Tokushima Fatty rats, and db/db mice, kidney Ang II and AGT are increased both before and after the development of kidney damage (Nagai et al., 2005; Miyata et al., 2008), although not all investigators agree (Leehey et al., 2008).