Yet, Wang et al. (2017c) reported that the AT1 receptor–β-arrestin–ERK1/2 signaling pathway is responsible for the development of renal fibrosis, whereas Carneiro de Morais et al. (2015) observed that TRV120023 inhibits NHE3 in opossum proximal tubule cells. The gene discussed is MAPK3; the disease is renal fibrosis.