Damage to the proximal tubule or changes in megalin function will alter AGT reabsorption, and impaired AGT reabsorption has been observed in DKD (Tang et al., 2019) and inherited kidney diseases such as Dent’s disease (Roksnoer et al., 2016a) and autosomal dominant polycystic kidney disease (ADPKD) (Salih et al., 2017). This evidence concerns the gene LRP2 and autosomal dominant polycystic kidney disease.