NFKB1 and injury: For example, genetic and pharmacological Mas receptor deficiency has been reported to prevent high-fat diet–induced kidney injury (Kong et al., 2021), abolish salt-sensitive hypertension (Heringer-Walther et al., 2012), reduce kidney damage in models of kidney injury (e.g., unilateral ureteral obstruction and ischemia/reperfusion injury) (Esteban et al., 2009), and inhibit NF-κB activation and thus the upregulation of proinflammatory cytokines (Esteban et al., 2009).