AGT and diabetic kidney disease: Interestingly, Ang II increased renal AGT mRNA via its AT1 receptor, thus potentially creating a feed-forward loop that might contribute to the development of diabetic kidney disease (DKD), also because high glucose similarly increases renal AGT mRNA (Gonzalez-Villalobos et al., 2008; Nishiyama et al., 2008; Nishiyama and Kobori, 2018).