Crowley et al. (2005, 2006) used a kidney crosstransplantation strategy to generate mice expressing AT1 receptors either only within or only outside the kidney, thus demonstrating that activation of renal AT1 receptors induced Ang II–dependent hypertension whereas exclusive extrarenal AT1 receptor stimulation was insufficient to cause hypertension. The gene discussed is AGTR1; the disease is Hypertension.