GPT and fibrosis: In order to complete the results of this analysis a significant larger decrease of ALT was also observed for +S—fibrosis progression compared to -S + fibrosis progression (mean decrease ± SD: -66.0±74.2U/L vs. -51.5±68.0U/L; p<0.001) and for AST a significant difference in decrease was observed for -S + fibrosis progression vs. -S—fibrosis progression (mean decrease ± SD: -39.5±57.1U/L vs. -35.6±42.1U/L; p<0.05).